The Role of Anemia Alongside the Investigation of Involved Clinical Parameters in Breast Cancer and Their Pathologic Association with Grading and Staging at Different Ages
نویسندگان
1 Department of Pathology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2 Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran
3 Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran
4 Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran
5 Clinical Research Development Unit, Porsina Hospital, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
6 Department of Medical Ethics, Guilan University of Medical Sciences, Rasht, Iran
7 Clinical Research Development Unit of Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran
doi
10.22034/ircmj.2025.481052.1511چکیده
Background and Objectives: Breast cancer is one of the common problems of women, and anemia is another serious disorder that is associated with this condition. In this study, we aimed to examine anemia in breast cancer patients and its relationship with their various pathological factors and tumor grade, and stage at different ages. Methods: In this retrospective case-control study, the information of patients who were diagnosed with breast cancer and underwent surgery at Razi Hospital in Rasht, and their tissue samples were examined in the pathology laboratory, was collected. In this way, the patients were divided into anemic and non-anemic groups, and their pathology reports and laboratory parameters were examined and statistically analyzed. Results: In this investigation, a total of 90 patients' pathology reports and laboratory findings were examined. Of the participants, 72 were identified as anemic, while 18 were non-anemic. The mean age of the cohort was 11.81±54.83. The study demonstrated a substantial correlation between anemia and advanced tumor stage (P < 0.001) as well as higher tumor grade (P = 0.001). Among anemic patients, prominent proportions exhibited nipple involvement (80%), simultaneous skin involvement (40%), vascular invasion (71%), lymphatic invasion (84%), neuronal invasion (57%), and necrosis in their pathological samples (41%). On the other hand, within the non-anemic group, none of the patients displayed nipple involvement, while smaller percentages had skin involvement (22%), vascular invasion (17%), lymphatic invasion (28%), neuronal invasion (17%), and necrosis in the pathological membrane (11%). Conclusion: Anemic patients had a significantly higher degree of tumor at the time of diagnosis, and their tumor was at a higher stage than that of non-anemic patients. Vascular invasion, lymphatic invasion, and neuronal invasion in pathological samples were significantly less in the non-anemic group, and generally, based on multiple analyses, and in the matched model, hematocrit variable and lymphatic invasion had the greatest predictive effect.
