فهرست نشریات علمی دسترسی آزاد ایران

   Background and Objectives: Both arthritis and low bone mineral density (LBMD) conditions are emerging as leading global causes of disability. Therefore, the study aims to report the associations between sex hormones, arthritis, and LBMD among different sexes and age groups, and provide a basis for the prediction of arthritis and LBMD.While in different sexes and ages, the associated sex hormone indicators vary to predict arthritis and LBMD. The results of this study may help clinicians monitor specific arthritis and LBMD by measuring sex hormone levels at an early stage.   Methods: In this cross-sectional analysis, data for this analysis were obtained from the 2013-2016 NHANES dataset including a total of 4950 participants, available on the official NHANES website. We compared categorical and continuous variables using chi-squared test or T-test. And binary logistic regression was conducted to analyze the association between sex hormone with arthritis and LBMD groups. Furthermore, to evaluate the performance of the indices, we examined the receiver operating characteristic curves (ROC).   Results: In this cross-sectional analysis, we observed that elder people (above 35) tend to be more associated with arthritis and LBMD problems in general, particularly the female group. Estradiol (E2) and (total testosterone) TT/E2 are the two most important indicators in the elder female. E2 is the protective factor to female arthritis (OR=0.99, 95%CI(0.99,1.00), P=0.030) and LBMD (OR=0.99, 95%CI(0.98, 0.99), P<0.001); while TT/E2 is the risk factor to female arthritis (OR=1.06, 95%CI(1.00,1.13), P=0.046) as well as LBMD (OR=1.13, 95%CI(1.03, 1.23), P=0.007).   Conclusion: Our findings indicated that estradiol and aromatase activity exert a protective effect against arthritis and LBMD, while the free androgen index (FAI) was found to have a protective effect against arthritis in males. This study explored a sex hormone regimen by extensively examining the associations between sex hormones and the dual health issues of arthritis and LBMD.