فهرست نشریات علمی دسترسی آزاد ایران

Background and Objectives: Metabolic syndrome is common in nonalcoholic fatty liver disease (NAFLD), and the serum uric acid to creatinine (sUA/Cr) ratio may indicate risk differently in men and women. This study explored the interplay that existed between the ratio of sUA/Cr and NAFLD risk with metabolic syndrome (MetS) across different genders.   Methods: The cross-sectional study included 795 women and 2879 men who underwent physical examinations, consumed < 140 g/week and 210 g/week of alcohol, respectively, and tested negative for viral hepatitis. Participants were categorized based on the presence of NAFLD, identified through abdominal ultrasound. A logistic regression (LR) analysis was conducted to examine variables linked to NAFLD, estimating the adjusted odds ratio (OR) and performing an ROC curve analysis.   Results: In our study of 2621 NAFLD participants (524 women and 2097 men), women with NAFLD exhibited significantly higher baseline levels of age, BMI, SBP, TG, TC, FPG, ALT, AST, GGT, LDL, sUA, and sUA/Cr compared to those without NAFLD. Similarly, men with NAFLD had significantly elevated baseline as females except for age, SBP, AND LDL, unlike their non-NAFLD counterparts. The results reveal that women with NAFLD exhibit significantly higher sUA/Cr levels compared to those without the condition, with an adjusted OR of 1.181 for each unit increment in sUA/Cr. In females with MetS, the SUA/Cr AUC was 0.608 (95% CI: 1.038 to 1.344), with a cut-off point of 5.50 and P < 0.001. The sUA/Cr were not associated with NAFLD presence in males.   Conclusion: The study demonstrates a significant interplay between increased sUA/Cr and ultrasound-diagnosed NAFLD with MetS in healthy adults. The sUA/Cr could represent a dependable indicator to predict NAFLD in females with MetS.