فهرست نشریات علمی دسترسی آزاد ایران

Background and Objectives: Red blood cell alloantibodies are a major cause of peri- and post-transfusion problems, especially in frequently transfused individuals. To obviate this, it is essential to ensure of the compatibility between donors and recipients with regard to potential antigenic variations and their corresponding alloantibodies. This study aimed to assess the incidence of unexpected red blood cell alloantibodies among healthy blood donors at a referral center in southeastern Iran.   Methods: This retrospective investigation was conducted from February 2024 to July 2024 at the Kerman Blood Transfusion Center, involving 400 healthy blood donors. Sera from these blood donors were subjected to antibody screening using commercial red cell alloantibody screening and identification panels. Additionally, donor phenotyping was conducted for ABO, Rh, and Kell blood group systems. Data analysis employed escriptive statistics to determine frequencies and percentages.   Results: Unexpected alloantibodies were detected in 11 out of 400 donors screened (2.75%), including 7 with alloantibodies and 4 with autoantibodies. Regarding blood groups phenotypes, "D" and "k" antigens were positive in 94.25% and 96% of the donors, respectively. Regarding ABO phenotyping, O, B, A, and AB had the respective frequencies of 38%, 26%, 25.25%, and 10.75%. The most common alloantibodies were anti-M (0.75%), anti-D (0.5%), and anti-Lewis (0.5%).   Conclusion: Both warm- and cold-reacting alloantibodies were found among healthy donors, suggesting that caution ought to be taken in donor blood typing, especially for the ABO group system. Also, antibody screening and identification should be considered in donated blood units to minimize transfusion-related risk in recipients.