فهرست نشریات علمی دسترسی آزاد ایران

Background and Objectives: As altitude increases, the physiology of the lungs and heart changes. We want to study how altitude affects right ventricular function using the TAPSE/PASP ratio, a non-invasive measure of right ventricular contractility and its interaction with the pulmonary artery. To contribute to clinicians' understanding of how the right ventricle adapts to changes in oxygen pressure by assessing its function at different altitude levels.    Methods: Our study was a prospective observational cross-sectional study involving 190 participants. These participants were divided into two groups based on altitude: 95 from Malatya (950 meters) and 95 from Balıkesir (70 meters). We used echocardiography to measure TAPSE and PASP and then calculated the TAPSE/PASP ratio. The statistical analysis employed a combination of descriptive measures and inferential tests, which included Chi-square tests and multiple linear regression analysis, to identify the predictors of outcomes.    Results: TAPSE and TAPSE/PASP ratios were significantly higher in the high-altitude group (950 meters) than those at lower altitudes (70 meters) (P<0.001, t= -7.96 and P<0.001, t= -7.97, respectively.) The TAPSE/PASP ratio is significantly predicted by altitude in the regression model (ß=0.474, P<0.001). The change in altitude explains about 28% of the variance in the TAPSE/PASP ratio.    Conclusion: Currently, assessing right ventricular function involves TAPSE and PASP values and the TAPSE/PASP ratio. Our study revealed significant differences in TAPSE and the TAPSE/PASP ratio at different altitudes, providing enhanced insights into right ventricular function across these levels.