فهرست نشریات علمی دسترسی آزاد ایران

Background and Objectives: Obesity is growing one of the health problems in the world and is becoming pandemic. We aimed to evaluate the inflammatory parameters associated with cardiovascular diseases in morbid obese patients by comparing neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), and monocyte/ High-density lipoprotein (HDL) (MHR) ratios with the healthy group.   Methods: This is a retrospective observational study. A hundred patients who were diagnosed with morbid obesity by applying to Adana Training and Research Hospital Endocrinology and Metabolism Diseases polyclinic between January 2019 and December 2020 will be screened retrospectively. Seventy-two patients who were not diagnosed with obesity and any disease affecting the cardiovascular system will form the control group. Neutrophil/lymphocyte, platelet/lymphocyte, monocyte/HDL ratios of both groups will be calculated, recorded and evaluated. Statistical analysis was performed using SPSS 25.0 software.   Results: Compared to the control group, platelet (P=0.001), neutrophil (P=0.001), lymphocyte (P=0.001), glucose (P=0.001), and insulin levels (P=0.030), BMI (P=0.001), NLR (P=0.020), and MHR (P=0.005) were statistically significantly higher in the morbid obese group. The risk factors found to be significantly associated with morbid obesity in the multiple logistic regression analysis included insulin level (P=0.010, OR (95% CI): 1.037 (1.009-1.068)) and MHR (P=0.008, OR (95% CI): 18.726 (4.876-32.576)).   Conclusion: NLR and MHR are both cost-effective and straightforward to compute. Particularly, MHR could serve as a valuable indicator for anticipating cardiovascular ailments in individuals with obesity. We think that morbid obesity has an effect on inflammatory parameters associated with cardiovascular diseases.