فهرست نشریات علمی دسترسی آزاد ایران

Background and Objectives: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that can lead to joint damage and disability. Early and accurate prediction of its prognosis is crucial for timely intervention and improvement of patient outcomes. This work evaluated the accuracy of the musculoskeletal ultrasound combined with serum inflammatory factor (SIF) detection method in predicting the prognosis of RA.Methods: This was a research report. 80 patients with RA treated at Affiliated Northwest University, Third Hospital of Xi’an from February 2022 to May 2023 were recruited. Based on the prognosis, they were allocated into a good prognosis (GP) group (n=42) and a poor prognosis (PP) group (n=38). Musculoskeletal ultrasound, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and tumor necrosis factor-alpha (TNF-α) were measured in all patients. The Rheumatoid Arthritis Disease Activity Index (RADAI) was recorded before and after the patients were treated, and the accuracy of different indicators in predicting RA prognosis was compared. Data analysis was performed using SPSS 26.0. For categorical data, chi-square tests were conducted; for continuous data, t-tests were used. A P-value of <0.05 was considered statistically significant.Results:Musculoskeletal ultrasound showed that the blood flow parameter grading in the GP group was significantly different compared to the PP group (P=0.009), and the synovial proliferation parameter grading in the GP group also showed a significant difference when compared to the PP group (P=0.024). The levels of ESR, CRP, and TNF-α in patients increased with the increasing grades of synovial proliferation/blood flow parameters. Significant differences were observed in ESR (P=0.011), CRP (P=0.026), and TNF-α (P=0.009) levels among patients with different synovial proliferation parameter grades (P<0.05). After treatment, the RADAI score (P=0.038), CRP (P=0.002), ESR (P=0.011), and TNF-α (P=0.031) levels in the GP group were significantly lower than those in the PP group (P<0.05). The AUC for musculoskeletal ultrasound combined with CRP, ESR, and TNF-α in predicting PP in RA was significantly higher than that of musculoskeletal ultrasound (P=0.026), ESR (P=0.006), CRP (P=0.045), or TNF-α (P=0.033) alone (P<0.05).Conclusion:Musculoskeletal ultrasound jointed with SIFs demonstrated good accuracy and clinical significance in predicting the prognosis of RA.