فهرست نشریات علمی دسترسی آزاد ایران

Background and Objectives: The global increase in the elderly population has led to a significant rise in chronic diseases such as diabetes and hypertension. In Türkiye, individuals aged 65 and older are projected to constitute 11% of the population by 2025. These demographic shifts highlight the importance of understanding age-related biochemical changes in common chronic conditions.Objectives: This study aimed to examine the relationship between diabetes, hypertension, and selected oxidative stress parameters in individuals aged 65 and older, with the goal of identifying clinically relevant markers.    Methods: This cross-sectional study included 296 participants aged ≥65 who presented to Kula State Hospital in 2023. Individuals with smoking history, alcohol use, antioxidant supplementation, or other chronic diseases were excluded. Blood samples were analyzed for total thiol, malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant capacity (TOC), catalase, paraoxonase (PON1), arylesterase (ARE), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) using commercial kits. Independent-samples t-tests and Pearson or Spearman correlations were used. All assays were performed in duplicate with quality control; coefficient of variation values were <10%.   Results: Statistically significant differences were found between the control, diabetic, and hypertensive groups in oxidative stress markers, particularly MDA, 8-OHdG, and PON1. Diabetic individuals showed elevated oxidative damage and reduced antioxidant defenses.    Conclusion: Oxidative stress markers were significantly altered in elderly individuals with diabetes and hypertension. While these associations are notable, the cross-sectional design precludes causal inference. Routine assessment of oxidative stress may aid in risk stratification and management of elderly patients.