فهرست نشریات علمی دسترسی آزاد ایران

Background and Objectives: Coronary artery ectasia (CAE) is an uncommon vascular disorder involving the dilatation of coronary arteries, often linked to underlying inflammatory processes and impaired vascular function. Chemerin, an adipokine associated with inflammatory processes, metabolic control, and immune function, has been linked to cardiovascular disease mechanisms. This study explores its possible contribution to the development of CAE.    Methods: A total of 100 participants were selected from 2,568 patients who underwent coronary angiography. Participants were divided into two groups: 50 patients with isolated CAE and 50 individuals with normal coronary anatomy. Serum chemerin levels, laboratory and clinical parameters were compared.   Results: Serum chemerin levels (P<0.001) and high-sensitivity C-reactive protein (hs-CRP) levels (P<0.001) were higher in the CAE group compared to control group. Multivariate logistic regression analysis defined elevated chemerin (P<0.001) and hs-CRP (P=0.001) as independent predictors of CAE. ROC curve analysis revealed a serum chemerin cut-off value of 116 ng/mL for predicting CAE with 82% sensitivity and specificity (AUC: 0.877; 95% CI: 0.808–0.946).    Conclusion: The findings of this study reveal a notable correlation between increased chemerin concentrations and the presence of CAE, indicating that chemerin could be an important factor in its underlying pathophysiology.