The Association between Serum 25-Hydroxyvitamin D Levels and Psoriasis: A Meta-analysis Considering Measurement Method, Type of Psoriasis, Age, and Geographical Region
نویسندگان
1 Department of Nursing, The Fifth Affiliated Hospital of Xinjiang Medical University Urumqi, 830000, China
2 Department of Nursing, The Fifth Affiliated Hospital of Xinjiang Medical University Urumqi, 830000, China
3 Nursing College, Xinjiang Medical University, Urumqi, 830000, China
4 Nursing College, Xinjiang Medical University, Urumqi, 830000, China
5 Department of Nursing, The Fifth Affiliated Hospital of Xinjiang Medical University Urumqi, 830000, China
6 Department of Dermatology, The Fifth Affiliated Hospital of Xinjiang Medical University，Urumqi，830000，China
7 Department of Nursing, The Fifth Affiliated Hospital of Xinjiang Medical University Urumqi, 830000, China
8 Nursing College, Xinjiang Medical University, Urumqi, 830000, China
9 Department of Nursing, The Fifth Affiliated Hospital of Xinjiang Medical University Urumqi, 830000, China
doi
10.22034/ircmj.2025.474766.1406چکیده
Background and Objectives: 25-hydroxyvitamin D (vitamin D) deficiency is a risk factor for psoriasis, which is classified as an inflammatory disease that the immune system cannot regulate. This study investigated the correlation between serum vitamin D levels and psoriasis, considering the measurement method, type of psoriasis, patient age, and geographical region. Methods: Excluding non-original articles, case reports, and animal studies, PubMed, the Cochrane Library, Web of Science, and Embase were used to search for research papers. Results: There were 23 observational studies in which 1878 people with psoriasis and 7533 healthy individuals were studied. Psoriasis was associated with an overall decline in vitamin D levels compared with control individuals [effect size: -0.76 (-1.35, -0.17); P=0.015]. The use of a chemiluminescent immunoassay for measurement revealed a strong correlation between vitamin D levels and psoriasis compared with other methods [effect size: -0.88 (-1.74, -0.02); P=0.047]. No association was found between psoriasis and vitamin D levels in patients without arthritis compared to those with chronic plaque psoriasis [effect size: -0.54 (-1.02, -0.07); P=0.029]. Based on age, a significant association was found between vitamin D levels and psoriasis in middle-aged patients (40-59 years) [effect size: -0.79 (-1.27, -0.31); P=0.003]. The relationship between psoriasis and vitamin D levels was greater in Asia [effect size: -0.69 (-1.49, -0.01); P=0.04] and in developing countries [effect size: -0.69 (-1.37, 0.11); P=0.08]. These findings suggest that measurement method, patient demographics, and geographic factors play a significant role in the relationship between vitamin D levels and psoriasis. Conclusion: This meta-analysis highlights the need for a personalized approach to psoriasis management, considering demographic variations and vitamin D measurement methods.
