فهرست نشریات علمی دسترسی آزاد ایران

   Background and Objectives: The Worldwide incidence and mortality rate of head and neck squamous cell carcinoma (HNSCC) are increasing. This study was conducted with the aim to analyse the survival rate and identifying factors that influence survival outcomes in HNSCC patients.   Methods: We carried out a retrospective cohort study on patients with HNSCC presented to teaching hospitals for 5-year period. Clinical and Pathological characteristics of patients were collected. We assessed the overall survival rates and their relationship with treatment, demographic and pathological factors affecting patients’ survival.   Results: Seventy eight patients included in our study. The majority of participants were male (88.5%) and 9 (11.5%) were female, with median age of 62.85±14.97 years. The larynx was the most common primary tumor site. 28 patients (35.89%) passed away. The overall 2 -year and 5-year survival rates were 87.2% and 67.4%, respectively. The mortality rate was slightly increased in patients older than 60 years, female, smokers, invasive tumor stage, positive LMP and poorly differentiated tumours, though it was not significant. The lower risk of death in treated patients who revealed 3+ positive EGFR expression was meaningful (HR=0.56, P=0.015). The survival rate in p16-positive individuals was higher over time, although it was insignificant.   Conclusion: This retrospective cohort study identified that anti-EGFR agent therapy of HNSCC patients was the most important factor affecting survival. The highest risk factors for death for the elderly were poor tumor differentiation, smoking, and vascular invasion. The results emphasized that timely diagnosis, targeted therapy and reduction of smoking would improve the survival rate and patient care. In the current article, we  spotlight future perspectives for benefit of anti-EGFR in the era of immunotherapy.