Association of Inflammatory Factors with COVID-19 Outcomes: A Retrospective Cohort Study
نویسندگان
1 Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran
2 Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran
3 Department of Infectious Diseases, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
4 Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
5 Department of Hematology and oncology, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
6 Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
7 School of Medicine, Iran University of Medical Sciences, Tehran, Iran
8 Department of Internal Medicine, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
9 Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
doi
10.22034/ircmj.2024.459017.1207چکیده
Background and Objectives: The inflammatory factors included Neutrophil-to-Lymphocyte Ratio (NLR), Procalcitonin (PCT), mean platelet volume (MPV), C-reactive protein (CRP), Ferritin, Lactate Dehydrogenase (LDH) and Acute Physiology and Chronic Health Evaluation II (APACHE II) score can affect disease outcomes in COVID-19 patients, and can help us in estimating the higher chance of death in severe patients. Our goal was to present the association of inflammatory factors with COVID-19 outcomes. Methods: As a retrospective cohort study a total of 369 intubated or hospitalized COVID-19 patients in the ICU during the year of 2021, were enrolled. Demographic data of patients collected by a questionnaire included age, sex, clinical information, and calculated their Neutrophils/Lymphocytes ratio (NLR) using the first complete blood count (CBC), PCT, MPV, CRP, and APACHE II on admission. Results: Of 369 hospitalized patients with COVID19, the average NLR was 4.01 (95% CI: 3.58, 4.45) and the difference with non-intubated patients was 1.26 units (P<0.001). Intubated patients had much higher APACHE II score (29.18 (95%CI: 26.27, 32.08)) and difference of 6.49 units (P<0.001). Patients had an average CT severity of 29.18 (95%CI: 27.81, 30.54) and longer hospital stay was strongly and positively linked to higher NLR at baseline (P< 0.001; r=0.627). Conclusion: The study highlights that intubated COVID-19 patients exhibit significantly higher neutrophil-to-lymphocyte ratios and APACHE II scores compared to non-intubated patients, indicating a correlation between elevated NLR and prolonged hospital stays. These findings suggest that NLR may serve as a valuable prognostic marker in assessing the severity of COVID-19 in hospitalized patients.
