فهرست نشریات علمی دسترسی آزاد ایران

Background and Objectives: Recent studies have reported varying degrees of associations between the alterations of serum elements levels with the onset and severity of various autoimmune diseases. Therefore, we aimed to investigate the effects of changes in magnesium levels, which are either the primary or the essential cofactor in many metabolic and biochemical reactions, on the development of SLE.   Methods: This analytical cross-sectional study evaluated individuals suffering from SLE, visited between March 2021 and March 2022. Demographic data, clinical presentation, and laboratory indices related to SLE were documented in those meeting the eligibility criteria. Then, they were divided into different groups based on age, sex, and serum magnesium level, and their differences were analyzed.   Results: One hundred patients with SLE (90% women and 10% men) with a mean age of 41.7 years had (87%) normomagnesemia, 11% had hypomagnesemia (which were 100% women), and 2% had hypermagnesemia. serum magnesium was significantly lower in those with leukopenia than in those without leukopenia (P < 0.01). In addition, the mean serum magnesium levels were significantly different between patients based on their SLEDAI-2k classifications (P < 0.01) We found that as the disease activity increased, the serum magnesium level also increased, yet the latter never surpassed the normal upper limit.   Conclusion: Among the clinical manifestations of lupus, only serum magnesium was significantly lower in those with leukopenia than in those without leukopenia. Therefore, measuring magnesium in lupus patients with leukopenia should be considered. Of course, it should be noted that the small sample size affects the generalizability of the results, and a study with a larger sample size and a control group is recommended.