فهرست نشریات علمی دسترسی آزاد ایران

   Background and Objectives: Coronary slow flow (CSF) is a phenomenon whose pathophysiology is unclear and is associated with increased cardiac mortality. According to recent studies, serum apelin levels are associated with oxidative stress and inflammation, which may contribute to CSF pathophysiology. We aimed to investigate the possible correlation of serum apelin levels with CSF.   Methods: The study included 50 consecutive CSF patients and 50 consecutive patients with normal coronary flow (NCF). We compared serum apelin-13 and other clinical parameters between the groups.   Results: CSF group had significantly lower serum apelin levels than the NCF group (P<0.001). The multiple regression analysis suggested low apelin levels as an independent risk factor for CSF (P<0.001). We found that the number of TIMI frames was positively correlated with apelin levels (P<0.001, r=0.843). According to the receiver operating characteristic curve analysis, serum apelin levels were significant predictors of CSF treatment (P<0.001). We calculated a cut-off value of 2.7 ng/ml for serum apelin levels to predict CSF with 84% sensitivity and 64% specificity.   Conclusion: This study concluded that the CSF group had lower serum apelin levels than theNCF group. Apelin may have a role in CSF pathogenesis.