Evaluation Genes and Molecular Pathway Related Inflammation in Patients Undergoing Bariatric Surgery: Future Perspective
نویسندگان
1 Department of General Surgery, Lorestan University of Medical Science, Khorramabad, Iran
2 Department of General Surgery, School of Medicine, Tehran University of Medical Science, Tehran, Iran
3 Department of General Surgery, School of Medicine, Iran University of Medical Science, Tehran, Iran
4 Department of Anesthesiology, Rasoul-Akram Medical Center, Iran University of Medical Sciences, Tehran, Iran
5 Department of General Surgery, Lorestan University of Medical Science, Khorramabad, Iran
6 Department of Internal Medicine, School of Medicine Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran
doi
10.22034/ircmj.2024.199755چکیده
Background and Objectives: Recent evidence indicate that bariatric surgery reduces inflammation in obese individuals. However, comprehensive investigations using a systems biology approach to explore gene expression changes post-bariatric surgery for inflammation reduction remain lacking. Thus, this study aims to address this gap. Methods: GSE59034 dataset was used to obtain genes patients related bariatric surgery. The protein-protein interaction of the DEGs was designed by STRING database and visualized using Cytoscape. Hub genes were determined using the Cytohubba plugin of Cytoscape. Finally, the Kaplan-Meier plotter was used to investigate the overall survival of patients with OC according to the hub genes. Results: PPI network and hub gene analyses identified eight hub genes, including IL-10, TLR2, CCL2, CYBB, IL-18, and IL-10RA. Finally, overall survival analysis using the Kaplan-Meier plotter showed that all hub genes were related to the patients survival. Conclusion: Understanding pathways associated with hub gene expression informs treatment strategies. Additionally, exploring pathways activated by hub genes aids inflammation management post-surgery.
