فهرست نشریات علمی دسترسی آزاد ایران

   Background and Objectives: Chlorine gas is readily available as a chemical warfare agent (CWA) and a toxic industrial chemical (TIC). Lots of accidental chlorine releases have been reported worldwide. This review examined the harmful effects of chlorine gas exposure, including both acute and chronic toxicity, in people.   Methods: This systematic review was conducted to determine the acute and chronic toxic effects of acute chlorine gas exposure in subjects after accidental events. Original research studies on acute and chronic effects of patients acutely exposed to chlorine gas in industrial and accident events published in English until August 2023 were included. Related Mesh terms and keywords searched relevant studies from PubMed, Scopus, and Wiley databases.   Results: Overall, 34 eligible studies with 6301 individuals were included in the final assessment. Reports demonstrated that the early effects of acute exposure to chlorine gas vary from mucosal irritation to decrease, depending on the severity of the exposure. The most common chronic effects were the respiratory tract. The severity of complications depends on the dose and duration of chlorine exposure.   Conclusion: The findings showed that chlorine exposure could cause respiratory, vascular, cardiovascular, neurological, and psychiatric complications; therefore, it is recommended that subjects exposed to chlorine gas should be monitored regularly after hospital discharge.