Effect of medicinal syrup made from silkworm cocoon on mixed anxiety-depression disorder: A triple-blind randomized clinical trial
نویسندگان
1 Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Psychiatry, Orumiyeh University of Medical Sciences, Orumiyeh, Iran
3 Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
doi
10.32592/ircmj.2021.23.12.1345چکیده
OBJECTIVE: Silkworm cocoon produced by silkworms with the scientific name of Bombyx mori L. is a well-known medicinal agent mainly composed of proteins. This study was designed to assess the efficacy of syrup made from this natural agent on mild to moderate depression. METHODS: The study was conducted based on a triple-blind randomized clinical trial. A total of 60 patients with mixed anxiety-depressive disorder were randomized to receive either intervention (silk syrup + sertraline) or control (placebo syrup + sertraline) for 12 weeks. Depression and anxiety were assessed using the Beck Depression and Anxiety inventories at weeks 0, 6, and 12. RESULTS: Out of the subjects, 54 patients completed the trial in two groups of intervention (n=30) and control (n=24) and entered the final analysis. According to the results of this study, the mean of anxiety and depression scores in weeks 6 and week 12 was significantly lower in the intervention group than in the control group (P<0.001). CONCLUSION: Silk syrup can be beneficial for the management of anxiety and depression in mild to moderate MADD; therefore, it is suggested as an adjuvant treatment to increase the efficacy of conventional medications adopted for the treatment of MADD patients.
