Role of Neurosteroids in Catamenial Epilepsy

نویسندگان
Khalid, Areej ID 1
Najeeb, Muhammad ID 2
Najam, Asiya ID 3
Asif, Aysha ID 4
Aftab, Wajiha ID 5
Hannan, Abdul ID 6

1 HITEC Institute of Medical Sciences, Islamabad, Pakistan

2 CMH Lahore, Islamabad, Pakistan

3 Dow International Medical College, Islamabad, Pakistan

4 Dow International Medical College, Islamabad, Pakistan

5 Dow International Medical College, Islamabad, Pakistan

6 Dow International Medical College, Islamabad, Pakistan

doi
10.30491/ijmr.2025.523430.1332
چکیده

Catamenial epilepsy is a hormonally influenced seizure disorder where conventional antiepileptic drugs (AEDs) often show limitedefficacy. Neurosteroids—endogenously synthesized modulators of GABAergic inhibition—represent a promising, mechanismbased  alternative.  During  hormone-sensitive  phases  of  the  menstrual  cycle,  compounds  like  ganaxolone  may  help  restore inhibitory balance and enhance seizure control. Its safety profile appears favorable, with only mild side effects. However, m ore comprehensive  studies  are  required  to confirm  its  long-term  safety and  potency  in  comparison  with  traditional  antiepileptic drugs (AEDs).

کلیدواژه‌ها
seizures, Allopregnanolone, GABA-A Receptor Agonists, Menstrual Cycle/Physiology