Human papillomavirus infection and risk of breast cancer in Iran: a meta-analysis
نویسندگان
1 Department of Pathology, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran.
2 Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
3 MD, Pediatric Cardiologist, Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
4 Subspecialty Board in Oncology, Hematology and Stem Cell Transplantation, Board Certified Specialist in Internal Medicine, Department of Internal Medicine, Shahid Mostafa Khomeini Hospital, Ilam, Iran
5 Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
6 Subspecialist of Pulmonary Diseases, Board Certified and Assistant Professor of Internal Medicine, Department of Internal Medicine, School of Medicine, Shahid Mostafa Khomeini Hospital, Ilam University of Medical Sciences, Ilam. Iran.
doi
10.32592/ircmj.2021.23.7.646چکیده
Background: Breast cancer is the most common malignancy and a leading cause of death in women. Viruses are known to be the risk factors for breast cancer. The present study aimed to evaluate the association between human papillomavirus (HPV) and the development of breast cancer in Iranian women by a systematic review and meta-analysis. Methods: The international databases, including Web of Science, Embase, PubMed, Cochrane, and Scopus, were searched in this study. Furthermore, relevant studies published on the association between HPV and breast cancer were identified using the appropriate keywords. The data were analyzed in Stata software (version 14) using the random-effects model. Results: In total, 18 studies were found eligible to be included in this study. The total sample size was determined at 2466 cases with the mean ages of 47.25 and 39.9 years for experimental and control groups. The overall findings showed a significant relationship between developing breast cancer and HPV infection. The results also revealed that the HPV infection increased the risk of breast cancer in women 5.02 fold more than those without HPV infection (95% CI: 3.46-7.29, I2=65.2%, P=0.003). In addition, the prevalence of HPV infection among women with breast cancer was estimated at 25.66% (95% CI: 17.34-34.95, I2=86%, P=0.000). Conclusion: HPV infections, especially high-risk HPVs, are significantly frequent in breast cancer samples and should be considered an important risk factor for developing breast cancer.
