A Meta-Analysis of the Effects and Safety of Pulmonary Surfactants
نویسندگان
1 1. Department of Pediatric, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou 510630, China 2. Department of Pediatric, The Sixth People's Hospital of Huizhou, Huizhou 516211, China
2 Department of Pediatric, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou 510630, China
3 Department of Pediatric, The Sixth People's Hospital of Huizhou, Huizhou 516211, China
4 Department of Pediatric, The Sixth People's Hospital of Huizhou, Huizhou 516211, China
doi
چکیده
Context: The purpose of this analysis was to explore the effects and safety of Pulmonary Surfactants (PS) combined with budesonide in Bronchopulmonary Dysplasia (BPD) by a meta-analysis of Randomized Controlled Trials (RCTs). Evidence acquisition: Literature searches were performed in PubMed, the Cochrane Library, EMBASE, the China Knowledge Net- work, and the Wanfang database to collect data from RCTs. The primary outcomes were BPD incidence and BPD-related mortal- ity, while the secondary outcomes were BPD-related complications. Bias was evaluated by the Cochrane risk assessment tool. The RevMan 5.3 software was used for the meta-analysis, and the Eggers test was used for publication bias assessment. Results: A total of 720 subjects were enrolled from six RCTs, including 352 in the experimental group and 368 in the observation group. The BPD incidence (RR = 0. 42, 95% CI [0. 37, 0. 89], P < 0.001) and BPD-related mortality (RR = 0.54, 95% CI [0.38, 0.89], P < 0.05) differed significantly between the two groups. Significant differences were also found in intraventricular hemorrhage, infection/sepsis, Retinopathy of Prematurity (ROP), and Patent Ductus Arteriosus (PDA). There were no significant differences in the incidence of PDA, Neonatal Necrotizing Enterocolitis (NEC), hyperglycemia, and hypertension. Conclusions: The intratracheal instillation of pulmonary surfactants with budesonide can reduce the incidence of BPD and BPD- related mortality with no increased risk of short-term complications.
