A Comparative Study of the Effect of Oral Dextromethorphan and Placebo on the Pain After Vitrectomy Surgery: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
نویسندگان
1 Department of Anesthesiology and Pain Medicine, Iran University of Medical Sciences, Tehran, Iran
2 Pain Research Center, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
3 Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
4 Community Based Participatory Research Center, Iranian Institute for Reduction of High-Risk Behaviors, Center for Academic and Health Policy, Tehran University of Medical Sciences, Tehran, Iran
doi
10.5812/ircmj.64763.چکیده
Background: Postoperative pain is a major complication in patients undergoing eye surgery. N-methyl-D-aspartate (NMDA) recep- tor antagonists are widely used to manage postoperative pains. Dextromethorphan, as an NMDA antagonist, is commonly used as an oral drug. Objectives: This study was conducted to evaluate the effect of Dextromethorphan on post-operation pain and sedative effect in comparison to placebo. Methods: A double-blinded, placebo-controlled, randomized clinical trial, upon 60 patients undergoing vitrectomy surgery wasdone. Thirty patients received 30 mg oral Dextromethorphan before the operation, and 30 patients received a placebo. Post- operation pain and sedation were evaluated after zero, one, two, and six hours. Results: Post-operation pain was significantly lower in patients who received Dextromethorphan at zero, one, and two hours afteroperation (P < 0.001); however, not at six hours after operation (P = 0.11). Sedative effect was higher in the Dextromethorphan group at zero (P = 0.03) and one hour (P = 0.01) after operation. Conclusions: Prescribing oral Dextromethorphan before a vitrectomy surgery could reduce postoperative pain. It also has postop-erative sedation effects.
