A comparative study of interleukin 6 and 17 serum levels in patients undergoing coronary artery bypass surgery using off-pump and on-pump methods
نویسندگان
1 Department of Biology, Faculty of Science, Payam-e Noor University,Tehran, Iran
2 Clinical Research Development Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran
4 Department of Cardiovascular Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5 Department of Biology, Faculty of Science, Payam-e Noor University of Mashhad, Mashhad, Iran
6 Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
doi
10.30483/rijm.2020.254165.1019چکیده
Introduction: This study aims to investigate the role of coronary artery bypass graft (CABG) surgery by off-pump and on-pump methods in the severity of postoperative inflammation based on serum levels of interleukin 6 (IL6) and interleukin 17 (IL17).Methods: This is a cross-sectional study in which 39 patients’ candidate for CABG were evaluated in terms of serum levels of IL17 and IL6 before and after surgery in two groups of off-pump and on-pump CABG.Results: Thirty-nine patients with an average age of 63±8.9 in the on-pump group and 59±7.74 in the off-pump group were evaluat- ed. There was no significant difference between the two groups in terms of baseline information and underlying diseases. IL6 serum level (p=0.249) was not significantly difference between the two groups. However, IL17 serum level (p=0.012) demonstrated a signif- icant difference between the two groups.Conclusion: In general, the results of this study showed that increased IL6 serum level following coronary artery bypass was not different between the two methods of CABG surgery. Besides, IL17 exhibited a significant difference between the two groups that it was reduced in on-pump group after surgery. It can be due to special condition’s patients or low sample size of study. More- over, the postoperative complications were not significantly different between the two groups. This valuable outcome contradicts the popular belief that the use of
