Risk Factors of Rheumatoid Arthritis Development Among Females in North-West of Iran: A Case-Control Study
نویسندگان
1 Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, IR Iran
2 Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, IR Iran
3 Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, IR Iran
4 Rheumatology Section, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran
5 Rheumatology Section, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran
6 Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, IR Iran
7 Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, IR Iran
8 Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, IR Iran
9 Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, IR Iran
10 Department of Biochemistry and Dietetics, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, IR Iran
11 Danesh Laboratory, Tabriz University of Medical Sciences, Tabriz, IR Iran
doi
چکیده
Given the high prevalence of rheumatoid arthritis (RA) in females of reproductive ages, it seems that hormonal factorsmight be important in RA pathogenesis.Objectives: The current study aimed to investigate the association between females’ reproductive factors occurring prior to theonset of rheumatoid arthritis and the risk of RA development.Methods: This case-control study was conducted on 231 patients with RA and 238 controls among females aged 26 - 64 years old fromthe North-West of Iran. The adjusted risk of RA was assessed using multivariate logistic regression models.Results: Females 14 years old at menarche, were more likely to be at risk of RA (OR = 1.69; 95%CI: 1.08 - 2.64). Advanced maternalage at first delivery (OR = 1.91; 95%CI: 1.21 - 3.26) and having abortion (OR = 1.97; 95%CI: 1.23 - 2.99) significantly increased the risk ofRA. Post-menopausal status increased the risk of developing RA (OR = 2.97; 95%CI: 1.98 - 4.46). Longer duration of breast-feeding wasdetermined as significant protective variable for RA (P < 0.05). Subjects with oral contraceptives (OCs) use (OR = 0.36; 95% CI: 0.20 -0.64), parity (OR = 0.20; 95%CI: 0.06 - 0.70) or large number of children tended to show rather more reduced risk of RA.Conclusions: The risk of RA increased with delayed menarche, advanced maternal age at first delivery and early age at menopause.However, longer duration of breast-feeding, parity, large number of children and consumption of OCs were found as protectiveindependent variables against RA.
