The Role of Interleukin-17A (IL-17A) in Depression
نویسندگان
1 Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
2 Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
3 School of Psychology, Azarbaijan Shahid Madani University, Tabriz, IR Iran
4 Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
5 Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
doi
چکیده
The aim of this review was to address the recent data regarding the role of IL-17A in the pathogenesis of depression and itscomplications, such as cancer.Evidence Acquisition: This review article summarizes the recent data on the role of IL-17A in depression, using the PubMed andGoogle Scholar databases.Results: It has been documented that depression may alter the immune response via unknown mechanism/s. It is possible thatimmune responses and depression are linked via several molecules, including cytokines. IL-17A, a pro-inflammatory cytokine, participatesin the pathogenesis of several inflammatory-based diseases, such as autoimmunity.Conclusions: Due to the comorbidity of depression and chronic inflammatory processes, and depression’s effect on the immunesystem, it may be hypothesized that the IL-17A cytokine plays a key role in the pathogenesis of depression.
