فهرست نشریات علمی دسترسی آزاد ایران

The incidences of both gastroesophageal reflux disease (GERD) and metabolic syndrome (MetS) have increased in recentyears, and it has been suggested that there is a probable association between the two. The aim of this review is to clarify whether ornot MetS is a risk factor for the incidence of GERD.Evidence Aquisition: We searched the PubMed, ProQuest, Ovid, Science Direct, and Google Scholar databases up to February 2015regarding the relationship between GERD and MetS as found in observational studies. Any studies that evaluated the associationbetween the components of MetS and GERD, as well as any studies examining the association of MetS with Barrett’s esophagus oresophageal carcinoma, were excluded.Results: Thirteen studies met the eligibility criteria. The results of nine studies suggested that there was a higher prevalence ofMetS among patients with GERD (P < 0.05) and, thus, it could be considered as an independent risk factor for the incidence of GERD.However, in the one study was not observed significant association between GERD and MetS (P = 0.71). Two studies in which theprevalence of GERD was compared between individuals with and without MetS showed a higher prevalence of GERD in patients withMetS (P < 0.05). However, this finding was not observed in a similar study conducted among female participants, which reportedthat the different types of MetS were not important factors with regard to the prevalence of erosive esophagitis (P = Not significant).Conclusions: It can be concluded that MetS may increase the risk of GERD. Consequently, there might be potential benefits to treatingthe metabolic abnormalities in these patients.