Maternal Inactive Hepatitis B Status and Birth-Outcomes: A Systematic Review and Meta-Analysis
نویسندگان
1 Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran
2 Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
3 MSc of Epidemiology, Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, IR Iran
4 Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
5 PhD Student in Reproductive Health, Department of Reproductive Health, Student Research Committee,School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, IR Iran
6 PhD Student in Reproductive Health, Department of Reproductive Health, Student Research Committee,School of Nursing and Midwifery, Shahroud University of Medical
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چکیده
Hepatitis is a term used to describe any type of hepatitis inflammation. Screening for the virus antigen during pregnancyis mandatory in some parts of the world and is recommended in others. so that, most women are aware of and understand thedisease if they have it when they are pregnant. Thus, the major concerns of these women are both the virus transmission to thefetus and the effects of hepatitis B on pregnancy outcome.Evidence Acquisition: According to a specific protocol, we searched in the Pub med, Scopus, ISI web of science from 1990 to February2015 to find the original articles, which investigated the hepatitis B effects in pregnantwomenwith normal singleton pregnancywho were previously diagnosed with inactive CHB or were incidentally found to be HBsAg positive in routine antenatal blood test.We included any cohort, case control and cross sectional studies if they had a healthy control group and reported one or more consideredmaternal or prinatal outcomes in pregnant women. Meta-analysis was performed with Review manager 5.4 and Stata 11software. We assessed the effect size that was pooled odds ratio (OR) and 95% confidence intervals (CIs) using the random effectsmodel. We explored statistical heterogeneity using the chi-squared (Chi2), I2 and tau-squared (Tau2) statistical tests.Results: From a total of 156 identified studies, 56 studies were chosen for a detailed review, and 18 studies whichmet the inclusionand exclusion criteria were included in the meta analysis. Among the included studies, the outcomes were small for gestational age(SGA) large for gestational age (LGA), intra uterine growth restriction (IUGR), fetal distress, fifth minutes apgar score, first minuteApgar score, low birth weight (LBW) and Fetal Macrosomia.Conclusions: In this study, hepatitis B had a cause effect on LGA and fetal Macrosomia. Among the other considered adverse pregnancyoutcomes; it didn’t have any significant effect.
