فهرست نشریات علمی دسترسی آزاد ایران

Background: Gastric Helicobacter pylori is extremely common worldwide.Objectives: The aim of this study was to assess the effectiveness of combination of Nigella sativa and honey (Dosin) in eradicationof gastric H. pylori infection.Patients and Methods: Nineteen patients who had positive result for H. pylori infection by urea breath test (UBT) without a pasthistory of peptic ulcer, gastric cancer or gastrointestinal bleeding, were suggested to receive one teaspoon of the mixture of Dosin(6 g/day of N. sativa as ground seeds and 12 g/day of honey) three times a day after meals for two weeks. The second UBT was used todetect the presence of H. pylori four weeks after completion of the test. In addition, symptoms of dyspepsia were scored before andafter the study and analyzed with Wilcoxon signed-rank test.Results: Fourteen patients completed the study. Negative UBT was observed in 57.1% (8/14) of participants after intervention. Themedian and interquartile range (IQR) of total dyspepsia symptoms was significantly reduced from 5.5 (5 - 12) to 1 (0 - 4) (P = 0.005).All the patients tolerated Dosin except for one who was excluded due to mild diarrhea. No serious adverse events were reported.Conclusions: Dosin was concluded to be an anti H. pylori and an anti-dyspeptic agent. Further studies are recommended to investigatethe effect of Dosin plus antibiotics (concurrently or following another) on gastric H. pylori infection.