Grape Seed Extract Supplementation and the Effects on the Biomarkers of Oxidative Stress and Metabolic Profiles in Female Volleyball Players: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
نویسندگان
1 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran
2 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran
3 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran
4 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran
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doi
چکیده
Only limited data are available for evaluating the effects of the administration of grape seed extract (GSE) on themetabolic status of female volleyball players.Objectives: This study was conducted to determine the effects of GSE administration on the metabolic status of female volleyballplayers.Methods: This randomized, double-blind, placebo-controlled clinical trial was performed among 40 female volleyball players. Thesubjects were randomly divided into two groups, with members of the test group (n = 20) taking 300mgof GSE twice a day for eightweeks and members of the control group (n = 20) taking a placebo pearl for the same period. Fasting blood samples were takenbefore and after the eight-week intervention period in order to determine the related variables.Results: Supplementation with GSE resulted in a significant rise in the plasma glutathione (GSH) level (+265.5 344.2 vs. +2.2 378.2 mol/L, P = 0.02), as well as a significant decrease in the malondialdehyde (MDA) level (-1.4 2.0 vs. -0.2 1.2 mol/L, P =0.01) when compared to the placebo group. In addition, when compared to the group that received the placebo, the subjects whoreceived GSE had significantly decreased serum insulin concentrations (-23.4 23.4 vs. +1.8 25.2 pmol/L, P = 0.002), a decreasedhomeostasis model of assessment for insulin resistance (HOMA-IR) (-0.70.7 vs. +0.20.9, P = 0.002), and an increased quantitativeinsulin sensitivity check index (QUICKI) (+0.01 0.01 vs. -0.01 0.02, P = 0.03). The administration of GSE had no significanteffects on creatine phosphokinase (CPK), total antioxidant capacity (TAC), nitric oxide (NO), fasting plasma glucose (FPG), and lipidconcentrations when compared with the administration of the placebo. However, after controlling for baseline NO levels, age, andbaseline BMI, the changes in the plasma NO concentrations were significantly different between the two groups.Conclusions: In conclusion, taking GSE for eight weeks had beneficial effects on the plasma GSH,MDAlevels, and markers of insulinmetabolism of female volleyball players.
