The Relationship Between Coronary Artery Disease and Genetic Polymorphisms of Melanoma Inhibitory Activity 3
نویسندگان
1 Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
2 Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
5 Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
6 Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
7 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
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چکیده
Melanoma Inhibitory Activity 3 regulates the plasma level of LDL cholesterol. The c.3169 + 315G > A single-nucleotidepolymorphism of the MIA3 gene has been reported to be associated with serum coronary artery disease (CAD). However, there havebeen no studies analyzing the association of this polymorphism with CAD in Iranian individuals with CAD.Objectives: Therefore, in the present studywehave investigated the potential protective effect of the rs3008621 MIA3polymorphismin 188 subjects with and without CAD.Materials and Methods: Genotyping of the MIA3 gene was undertaken using TaqMan real-time PCR in all subjects. Anthropometricand biochemical features, including HDL, LDL, and TG were assessed in all subjects.Results: The CAD patients had significantly (P < 0.05) higher BMI and significantly higher levels of TG, LDL, SBP, and DBP, while thelevel of HDL was lower compared to that of the control group. the MIA3 gene polymorphism was not associated with CAD in ourpopulation sample.Conclusions: The MIA3 polymorphism is unlikely to play an important role in CAD in the Iranian population. However, furtherstudies are needed in a larger population to confirm this.
