Systemic Manifestation of Rotavirus Infection in Children: A Report of Three Cases
نویسندگان
1 Department of Pediatrics, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
2 Department of Pediatrics, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
3 Department of Pediatrics, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
4
5 Department of Pediatrics, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
6 Department of Pediatrics, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
7 Department of Pediatrics, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey
doi
چکیده
Rotavirus is a leading cause of acute gastroenteritis in children. Although the clinical complaints associated withrotavirus are generally gastrointestinal, including vomiting and diarrhea, data suggest that it can also cause symptoms that extendbeyond the gastrointestinal tract.Case Presentations: We report three pediatric cases of rotavirus infection: one accompanied by encephalopathy and two withelevated hepatic transaminase activity. The patients were admitted to Dr. Sami Ulus maternity and children’s health and diseasestraining and research hospital, Ankara, Turkey, from 2012 - 2014. The presented patients’ aspartate aminotransferase (AST) (1765-2614IU L-1) and alanine aminotransferase (ALT) (1448-3558 IU L-1) levels are, to date, the highest reported levels associated with rotavirusinfections, and suggest that the rotavirus can cause severe hepatic transaminase elevation.Conclusions: This report aimed to increase awareness of the occurrence of extra-intestinal systemic manifestations of rotavirusinfection. Although such cases may be rare, they still suggest that that rotavirus is a systemic viral infection.
