The Effect of Cumin cyminum L. Plus Lime Administration onWeight Loss and Metabolic Status in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Clinical Trial
نویسندگان
1 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran
2 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran
3 Barij Medicinal Plants Research Center, Kashan, IR Iran
4 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran
5 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran
6 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR Iran
7 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
doi
چکیده
Limited data are available regarding the effects of combined administration of Cumin cyminum L. and lime on weightloss and metabolic profiles among subjects with overweight subjects.Objectives: The current study aimed to assess the effects of combined administration of Cumin cyminum L. and lime on weight lossand metabolic profiles among subjects with overweight.Patients and Methods: This randomized double-blind placebo-controlled clinical trial was conducted on 72 subjects with overweight,aged 18 - 50 years old. Participants were randomly divided into three groups: Group A received high-dose Cumin cyminumL. and lime capsules (75 mg each, n = 24), group B low-dose Cumin cyminum L. and lime capsules (25 mg each, n = 24) and group Cplacebos (n = 24) twice daily for eight weeks.Results: After eightweeksof intervention, comparedwithlow-dose C.cyminumL. plus limeandplacebo, taking high-dose C.cyminumL. plus lime resulted in significant weight loss (in the high-dose group: -2.11.7 vs. in the low-dose group: -1.21.5 and in the placebogroup: + 0.2 1.3 kg, respectively; P < 0.001) and body mass index (-0.8 0.6 vs. -0.5 0.5 and +0.1 0.5 kg/m2, respectively; P <0.001). In addition, administration of high-dose C. cyminum L. plus limecomparedwith low-dose C. cyminum L. plus limeandplacebo,led to a significant reduction in fasting plasma glucose (FPG) (P < 0.001) and a significant rise in quantitative insulin sensitivitycheck index (QUICKI) (+ 0.02 0.02 vs. + 0.01 0.02 and 0.01 0.01, respectively; P = 0.01). Moreover, a significant decrease inserum triglycerides (-14.1 56.2 vs. +13.9 36.8 and + 10.6 25.1 mg/dL; respectively; P = 0.03), total-cholesterol (-18.4 28.6 vs.+8.628.5 and -1.024.8 mg/dL; respectively; P = 0.004) and low density lipoproteins- (LDL)-cholesterol levels (-11.820.7 vs. +6.523.2 and -2.920.4 mg/dL, respectively; P = 0.01) was observed following the consumption of high-dose C. cyminum L. plus limecompared with low-dose C. cyminum L. plus lime and placebo.Conclusions: Results of the current study indicated that taking high-dose C. cyminum L. plus lime for eight weeks among subjectswith overweight had beneficial effects on weight, BMI, FPG, QUICKI, triglycerides, total-cholesterol and LDL-cholesterol levels.
