Comparison of Hydrogel Produced by Radiation as Applied at the Research Center (Yazd Branch) With MaxGel and Routine Dressing for Second-Degree Burn Repair in Yazd Burn Hospital
نویسندگان
1 Dermatology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran
2 Dermatology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran
3 Dermatology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran
4 Physiology Department, Shahid Sadoughi University of Medical Sciencse, Yazd, IR Iran
5 Dermatology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran
6 Dermatology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran
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چکیده
Recently, the radiation application research center for the atomic energy organization of Yazd (Iran) has developeda hydrogel dressing which was evaluated for quality and safety in 2008. Its efficacy for assisting in the wound healing process wasapproved for animal use, and its use has proven to be more effective than a related Syrian material.Objectives: We have already confirmed the safety and efficacy of Irgel use on mice (1, 2), so this study was conducted in order tofurther evaluate its effectiveness onhumanburn wounds, and to compare its efficacy with MaxGel, another hydrogel. A randomizedclinical trial study was conducted to compare the efficacy of hydrogel produced by the radiation application research center (YazdBranch) with MaxGel and routine dressing on burn repair in the Yazd Burn hospital.Materials and Methods: In this study, 90 patients with second-degree burn injuries who were admitted to the Yazd Burn hospitalwere randomly divided into three equal groups. In the negative control group, the wounds were covered with sterile vaseline gauzefollowed by double sterile dry gauze and ultimately bandaged. In the test group, the wounds were covered by an Iranian hydrogelsheet (Irgel) instead of vaseline gauze, while in the positive control group, the wounds were covered by MaxGel instead of Irgel. Ateach visit (every other day), each dressing was renewed by its respective method and the wound area, pain score, and body temperaturewere recorded. At the beginning and at the end of the first and second week, five milliliters of venous blood were takenfrom all patients to evaluate hematologic parameters such as peripheral blood cell count, liver function, blood urea nitrogen, andcreatinine.Results: Before the intervention, the extent of the burns and pain sensations were quite similar among the different groups, but atthe second week, the burn areas and pain scores for the Irgel group were significantly less than those of the normal control and thepositive control groups (P < 0.05).Conclusions: Based on our findings, both gels assist in the process of burn wound healing and pain reduction more effectively ascompared with routine dressing. However, Irgel had better effects on wound healing and pain relief than MaxGel, which indicatesa better quality of Irgel for this particular kind of treatment.
