Application of Autologous Platelet-Rich Plasma (PRP) onWound Healing After Caesarean Section in High-Risk Patients
نویسندگان
1 Department of Obstetrics and Gynecology, ArashWomen’s Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
2
3 Department of Obstetrics and Gynecology, ArashWomen’s Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
4 Department of Obstetrics and Gynecology, ArashWomen’s Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
5 Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, IR Iran
6 Research Promotion Center, ArashWomen’s Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
doi
چکیده
Background: Platelet-rich plasma (PRP) is ahumanplasma product enriched by platelets, growth factors, and fibrinogen with highhemostatic and healing properties.Objectives: The aim of this study was to evaluate the effect of autologous PRP on wound healing in high-risk women undergoingcesarean sections.Patients and Methods: In this balanced, randomized, and controlled trial, 140 patients were admitted to Arash women’s hospital,Tehran, Iran from May of 2013 to November of 2014 for elective cesarean surgery. The patients were randomly assigned into twogroups. The intervention group received PRP after surgery, whereas the control group received the usual care. All patients wereevaluated at baseline, five days, and eight weeks after the cesarean section. The primary endpoint used the REEDA scale for assessingthe changes in wound healing. The secondary outcome measures used were the Vancouver scar scale (VSS) and the visual analogscale (VAS). All scale scores were analyzed using a repeated measures test for variance.Results: At the end of study, the PRP group showed a greater reduction in the edema ecchymosed discharge approximation (REEDA)score compared to the control group (85.5% reduction in the PRP group; 72% in the control group) (P < 0.001). Compared with thecontrol group, the PRP group had a significantly greater reduction in the VANscore, beginning on the fifth day after the cesarean section(-0.7, 38% reduction in PRP group; -0.8, 33% in control group) (P < 0.001), and this trend was stable at the end of the eighth week(-0.6, 54% reduction in PRP group; -0.3, 18% in control group). Furthermore, patients treated with PRP experienced a 93% reductionin the VAS score at the end of follow-up, but the control group only observed a 79% reduction (P < 0.001).Conclusions: It seems that applying PRP is an effective therapeutic approach for wound healing, and faster wound healing is expecteddue to the presence of more platelets and growth factors.
