فهرست نشریات علمی دسترسی آزاد ایران

Background: Mutations in the solute carrier family 22 member 3 (SLC22A3), lipoprotein (a)-like 2 (LPAL2), and the lipoprotein (a)(LPA) gene cluster, which encodes apolipoprotein (a) [apo (a)] of the lipoprotein (a) [Lp (a)] lipoprotein particle, have been suggestedto contribute to the risk of coronary artery disease (CAD), but the precise variants of this gene cluster have not yet been identifiedin Chinese populations.Objectives:We sought to investigate the association between SLC22A3-LPAL2-LPA gene cluster polymorphisms and the risk of CAD inthe Han Chinese population.Patients and Methods: We recruited 551 CAD patients and 544 healthy controls for this case-control study. Four SNPs (rs9346816,rs2221750, rs3127596, and rs9364559) were genotyped in real time using the MassARRAY system (Sequenom; USA) in the SLC22A3-LPAL2-LPA gene cluster. All subjects were Chinese and of Han descent, and were recruited from the First Hospital of Jilin Universitybased on convenience sampling from June 2009 to September 2012.Results: The frequency of the minor allele G (34.8%) in rs9364559 was significantly higher in the CAD patients than in the healthycontrols (29.4%) (P = 0.006). There was genotypic association between rs9364559 andCAD(P = 0.022), and these results still remainedsignificant after adjustment for the conventional CAD risk factors through forward logistic regression analysis (P = 0.020, P = 0.019).Haplotype analyses from different blocks indicated that 11 haplotypes were associated with the risk of CAD. Seven haplotypes wereassociated with a reduced risk of CAD, whereas four haplotypes were associated with an increased risk of CAD.Conclusions: Rs9364559 in the LPA genemaycontribute to the risk of CADin theHanChinese population; haplotypes which containrs9346816-G were all associated with an increased risk of CAD in this study.