فهرست نشریات علمی دسترسی آزاد ایران

Background: Body temperature is a critical criterion of health. Drugs and a variety of poisons can affect body temperature inpoisoned patients, causing hyperthermia and hyperpyrexia.Objectives: Our previous study’s findings in patients poisoned with organophosphate led us to the goal of this study: obtainingthe initial tympanic temperature in patients poisoned by a variety of toxins.Materials and Methods: A cross-sectional study reviewed the records of poisoned patients who were admitted to the toxicologicalintensive care unit (TICU) at Loghman Hakim hospital poison center (LHHPC) from February 2014 to February 2015. The datacollected included gender, age, type of poisoning, the season during which poisoning occurred, vital signs, initial tympanic temperature(first four hours), presence of seizures, white blood cell (WBC) count, creatinine phosphokinase (CPK), length of stay andpatient outcome. We determined the mean (SD) for normally distributed continuous variables, the median and interquartile rangefor non-normally distributed continuous variables, and the absolute and relative frequency (%) for categorical variables. All weredetermined using SPSS version 16.Results: Data were collected from 310 eligible patients. The mean patient age was 32.65 (with a standard deviation of 14.40). Of thepatients in the study, 183 (59%) were male. Intentional poisoning in an attempted suicide was documented in 253 (81.6%) patients. Themost prevalent poisoning agent was aluminum phosphate (18.70%), followed by methadone (10%) and opium (10%). Seventy percentof the patients (n = 217) were diagnosed and classified with fever or hyperthermia. A temperature 40°C was detected in just threecases. The highest mean temperature was found in patients poisoned with amphetamine, organophosphate and tramadol. Patientswith alcohol and phenobarbital poisoning were included in the sample, but these patients were not diagnosed with hypothermia.WBC 10,000 cells/mL and CPK 975 IU/L were recorded in 57.7% and 13.2% of subjects, respectively.Conclusions: Body temperature changes in human poisonings are a matter in need of special attention. A literature review did notreveal any controversy over hypothermia, but poisoning cases exhibit a variety of patterns of fever and hyperthermia. If there areno limits to the diagnosis of fever and hyperthermia, all cases with a poor prognosis which fail to respond to treatment could becategorized as drug-induced hyperthermia. Therefore, a different approach is needed for poisoning cases.