Enigmatic Inv(9): A Case Report on Rare Findings in Hematological Malignancies
نویسندگان
1 Regional Cancer Centre, Division of Cancer Research, Medical College PO, Thiruvananthapuram-695 011, Kerala, India
2 Regional Cancer Centre, Division of Cancer Research, Medical College PO, Thiruvananthapuram-695 011, Kerala, India
3 Regional Cancer Centre, Division of Cancer Research, Medical College PO, Thiruvananthapuram-695 011, Kerala, India
4 Regional Cancer Centre, Division of Cancer Research, Medical College PO, Thiruvananthapuram-695 011, Kerala, India
5 Regional Cancer Centre, Division of Medical Oncology, Medical College PO, Thiruvananthapuram-695 011, Kerala, India
doi
چکیده
Inversion of chromosome 9 had been widely discussed among geneticists and evolutionary biologists because ofits significant impact on various hereditary disorders and in the evolution of man. The role of such inversions in human diseaseevolution is an area hitherto unclear.Case Presentation: We present the case of a chronic myeloid leukemia (CML) patient who showed intermittent relapse on treatment,with a rare appearance of clones with dual inversion (9) breakpoints [inv(9)(p22q34); inv(9)(p11q21)]. We also present thefirst report of inv(9)(p11,q13) as the sole abnormality in a patient with chronic myeloproliferative disorder(CMPD). Both the patientsregistered in 2012 and were from Kerala, India.Conclusions: Both the cases discussed in our study have inv(9) as the sole abnormality and are found to confer a relatively poorprognosis.
