Interleukin-2 Expression in Lupoid and Usual Types of Old World Cutaneous Leishmaniasis
نویسندگان
1 Department of Medicine, Unit of Dermatology and Venereology, Solna, Karolinska Instititutet, Stockholm, Sweden
2 Department of Dermatology, Faculty of Medicine, Rsearch Center for Skin Disease and Cutaneous Leishmaniasis, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran
3 Department of Medicine, Unit of Dermatology and Venereology, Solna, Karolinska Instititutet, Stockholm, Sweden
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چکیده
Interleukin (IL)-2 plays a central role in T cell-dependent immune responses.Objectives: We conducted this study to determine and compare IL-2 expression in lupoid and usual types of Old World Cutaneous Leishmaniasis (OWCL), using immunohistochemistry.Patients and Methods: Thirteen paraffin-embedded specimens of lupoid and 12 specimens of usual types of OWCL were used. A mouse monoclonal anti IL-2 antibody was used for staining by the envision technique.Results: There were strongly stained discrete foci of staining through inflammatory infiltrates of dermis and also in basal layers of epidermis and adnexal structures, with a distinctive pattern of hot spot activity foci (mean of 9.31 ± 6.4 versus 8.17 ± 6.9 foci per HPF for lupoid and usual types, respectively). The expression of IL-2 had no correlation with the pattern of granulomatous inflammation (tuberculoid, sarcoidal or mixed suppurative).Conclusions: Interleukin-2 takes part in the immunological response of the granulomatous reaction of OWCL and is not statistically different between lupoid and usual types (P = 0.674).
