Cytotoxic Properties of Some Medicinal Plant Extracts from Mazandaran,Iran
نویسندگان
1 Department of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, IR Iran
2 Department of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, IR Iran
3 Department of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, IR Iran
4 Department of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, IR Iran
5 Department of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, IR Iran
doi
چکیده
Background: It was shown that plants derived agents are being used for treatment of cancer. In this study, crude ethanolic extract of Consolida orientalis L., Ferula assa-foetida L., Coronilla varia L., Orobanche orientalis G. Beck were screened in vitro for cytotoxic activity on Hela (Human cervical carcinoma) cell line.Objectives: We performed the present study to evaluate the in vitro cytotoxic activity of four plant extracts that we gathered from north of Iran, MazandaranMaterials and Methods: Hela cells were treated with various concentrations of individual samples (0.0312, 0.0625, 0.125, 0.25, 0.5, 1, 2.5, 5,7.5 and 10 mg/ml) for 72 hours. Cell proliferation measured by MTT assay.Results: Result from the performed assay showed that ethanolic extract of Consolida orientalis L., Ferula assa-foetida L., Coronilla varia L. has more significant cytotoxicity effect on Hela cell line than Orobanche orientalis G. Beck.Conclusions: Extracts of the Consolida orientalis L., Ferula assa-foetida L., Coronilla varia L. could be considered as potential sources of anticancer compounds but further studies are necessary for isolation and identification of biologically active substances.
