Alpha-1 Antitrypsin Deficiency in Iranian Patients with Chronic Obstructive Pulmonary Disease
نویسندگان
1 1 Department of Pathology, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran 2 Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Department of Pathology, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
5 Department of Pathology, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
6 Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
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چکیده
Background: Alpha-1 antitrypsin deficiency is a genetic disease which affects both lung and liver. This disease is a recognized factor for chronic obstructive pulmonary disease (COPD). However its importance as the cause of COPD in a country such as Iran is unclear.Objectives: This study was conducted to find out the role of α-1 antitrypsin deficiency as a cause of COPD in Iranian patients.Materials and Methods:The serum concentration of α-1 antitrypsin was determined and the genotype of α-1 antitrypsin was also evaluated by PCR-RFLP in 130 patients with COPD and 50 normal healthy blood donors.Results: No α-1 antitrypsin deficient case was found in normal healthy people and COPD patients.Conclusions: Our results clarify that deficiency of α-antitrypsin is not a major cause of COPD in Iranian patients.
