Investigate the Role of Glutathione S Transferase (GST) Polymorphism in Development of Hypertension in UAE Population
نویسندگان
1 Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates
2 Department of Biochemistry, Dubai Medical College, Dubai, United Arab Emirates
3 UAE University, Faculty of Medicine & Health Sciences, Al Ain, United Arab Emirates
4 Dubai Medical College, Dubai, United Arab Emirates
doi
چکیده
Background: GST is a family of enzymes that are important in protection of the body against oxidative stress. Objectives: Investigate the association between GSTT1 and GSTM1 polymorphism and hypertension.Materials and Methods: GSTT1 and GSTM1 genotypes were detected by PCR. The fragments were then analyzed by agarose gel electrophoresis.Results: There is no significant association between GSTT1 & GSTM1 polymorphism and hypertension (OR = 2.4, P >0.05 and OR = 1.6, P > 0.05)Conclusions: GSTT1 & GSTM1 polymorphism can be considered a risk factor for hypertension.
