Age-Specific Reference Intervals for Routine Laboratory Biochemical Tests in The Iranian Adolescent Girls
نویسندگان
1 Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
4 Social Determinants of Health Research Center, Mashhad University of Medical sciences, Mashhad, Iran.
5 Social Determinants of Health Research Center, Mashhad University of Medical sciences, Mashhad, Iran.
6 Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
7 Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
8 Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
9 Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
10 International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
11 Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
12 International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
13 International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
14 International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
15 Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
16 Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
17 Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
18 International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
19 Social Determinants of Health Research Center, Mashhad University of Medical sciences, Mashhad, Iran.
doi
10.22038/jctm.2022.67858.1398چکیده
Introduction: For interpretation of the most common biochemical markers reference intervals (RIs) are widely considered and reported. Therefore, in this study, we aimed to determine age-specific RIs for some biochemical tests by removing and/or limiting critical gaps including sex, age group, geographical region, measurement device, and type of kits and reagents for routine laboratory biochemical variables in healthy adolescent girls aged 12-19 years.Materials and Methods: In this cross-sectional study a total of 1026 adolescent girl was recruited. According to the study aim, the levels of serum for some routine biochemical tests were measured on a BT-3000 auto-analyzer. On the basis of the non-parametric rank method and by use of CLSI Ep28-A3 guidelines, we determined age-specific RIs, including confidence interval 90%, under specific exclusion criteria.Results: Age partitioning was required for none of the upper and lower limits of biochemical markers. All Serum biochemical tests concentration remained relatively constant throughout the age range. Conclusion: By removing and/or limiting critical gaps involved in reference values of biochemical tests, it has provided an important understanding of metabolic processes and it has facilitated clinical application to track different diseases better
