Serum Level of Matrix Metalloproteinase-3 in Patients with Oral Lichen Planus
نویسندگان
1 Department of Oral Medicine, Dental School
2 Shiraz Institute for Cancer Research
3 Department of Oral Medicine, Dental School
4 Department of Prosthodontics, Dental School
5 Department of Oral Medicine, Dental School
6 Health Policy Research Center
7 Department of Oral Pathology, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran
doi
چکیده
Background: Oral Lichen planus (OLP) is a chronic lesion of the oral mucosa with unknown origin. Basement membrane changes are common in OLP and may be mediated by proteases such as matrix metalloproteinase (MMPs) and mast cell chymase. The aim of our study was to evaluate the level of serum MMP-3 in OLP compared to normal individuals and assess its clinical significance.Methods: Thirty four serum samples from patients diagnosed with OLP (12 males, 22 females, age: 42.2±10.8 years) and 34 serum samples from healthy control subjects (11 males, 23 females, age: 42.5±13.3 years) were collected and MMP-3 concentration was measured by ELISA.Results: The serum MMP-3 level in OLP patients was higher (21.64±24.31 ng/ml) compared with healthy controls (16.52±23.63 ng/ml), but showed no statistically significant difference. A statistically significant difference was demonstrated between the two types of OLP, being more pronounced in the erosive/atrophic form 6).Conclusion: The different clinical appearances of OLP are associated with significant differences in MMP-3 serum level.
