The Effect of Calendula Officinalis in Therapy of Acetic Acid Induced Ulcerative Colitis in Dog as an Animal Model
نویسندگان
1 Laparascopy Research Center,
2 Laparascopy Research Center,
3 Colorectal Disease Research Center,
4 Stem Cell and Transgenic Technology Research Center,
5 Stem Cell and Transgenic Technology Research Center,
6 Stem Cell and Transgenic Technology Research Center,
7 Colorectal Disease Research Center,
8 Colorectal Disease Research Center,
doi
چکیده
In patients with ulcerative colitis (UC), the repeated cycle of injury and repair of intestinal mucosahas been reported to increase the risk of colon cancer. So, a safe and efficient therapy is required for thetreatment and prophylaxis for the disease.This study aims to investigate the efficacy of Calendula officinalisextract in treatment of experimentally induced ulcerative colitis in dog animal model.Methods: During fall 2010, 10 out-bred female German dogs (1-2 years old; weighs of 20-25 kg) were enrolled.Ulcerative colitis was induced with 6% acetic acid as enema and method of treatment was retrograde (via enema)too by C. officinalis.Results: Loose stools, diarrhea, gross bleeding and loss of body weight happened after administration of aceticacid and crypt damage, loss of epithelium, infiltration of inflammatory cells and depletion of goblet cells werenoticed histologically. C. officinalis could successfully resolve the damages of UC.Conclusion: Treatment with C. officinalis can broaden the current therapy options for UC.
