An Unusual Presentation of Granulomatosis with Polyangiitis
نویسندگان
1 Senior Resident, Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Dehradun, Indian
2 Pathologist, Department of Pathology, Himalayan Institute of Medical Sciences, Dehradun, Indian
3 Resident, Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Dehradun, Indian
4 Internal Medicine, Pulmonologist, Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Dehradun,Indian
5 Critical Care Medicine, Department of Critical Care Medicine, Himalayan Insitute of Medical Sciences, Dehradu, Indian
doi
10.22038/jctm.2017.24298.1135چکیده
The granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a pauci-immune vasculitis involving small- and medium-sized blood vessels. Classically, the patients inflicted with this disease present with a triad of necrotizing granulomatous inflammation of the respiratory tract, cutaneous necrotizing vasculitis, and glomerulonephritis (GN). The antinuclear (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA) are considered as relatively specific markers of the disease. Herein, we presented the case of a patient who initially presented with sepsis but did not respond to the conventional antibiotics and later diagnosed with GPA.The granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a pauci-immune vasculitis involving small- and medium-sized blood vessels. Classically, the patients inflicted with this disease present with a triad of necrotizing granulomatous inflammation of the respiratory tract, cutaneous necrotizing vasculitis, and glomerulonephritis (GN).The antinuclear (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA) are considered as relatively specific markers of the disease. Herein, we presented the case of a patient who initially presented with sepsis but did not respond to the conventional antibiotics and later diagnosed with GPA.
