The Healing Effect of Bioglue in Articular Cartilage Defect of Femoral Condyle in Experimental Rabbit Model
نویسندگان
1 Stem Cell and Transgenic Technology Research Center, Department of Pharmacology, Shiraz University of Medical Sciences,
2 Stem Cell and Transgenic Technology Research Center, Department of Orthopedic Surgery,
3
4 Department of Veterinary Surgery, School of Veterinary Medicine, Shiraz University,
5 Stem Cell and Transgenic Technology Research Center, Department of Orthopedic Surgery,
6 Stem Cell and Transgenic Technology Research Center, Department of Orthopedic Surgery,
7 Stem Cell and Transgenic Technology Research Center, Department of Pathology
8 Division of Animal Health Management, School of Veterinary Medicine, Shiraz University,
doi
چکیده
Background: The full-thickness articular cartilage defects of knee have a poor healing capacity that may progressto osteoarthritis and need a knee replacement. This study determines the healing effect of bioglue in fullthicknessarticular cartilage defect of femoral condyle in rabbit.Methods: Forty-eight male rabbits were randomly divided into four equal groups. In group A, 4 mm articularcartilage defects were created in the right and left medial femoral condyles. Then a graft from xiphoid cartilagewas transferred into the defect together with a designed bioglue and the knees were closed. In group B, an articularcartilage defect was created identical to group A, but the defect size was 6 mm. In group C, 4 and 6 mmarticular cartilage defects were created in the right and left medial femoral condyles respectively. The graft wastransferred into the defect and the knees were stitched. In group D, articular cartilage defects were created similarto group C, just filled with bioglue and closed. The rabbits were euthanized and subgroups were defined asA1, B1, C1 and D1 after 30 days and A2, B2, C2 and D2 after 60 days. The cartilages were macroscopically andhistologically investigated for any changes.Results: Microscopic and macroscopic investigations showed that bioglue had a significant healing effect in thefemoral condyle.Conclusion: Addition of bioglue can effectively promote the healing of articular cartilage defects.
