Association between TNF-Alpha (-857) Gene Polymorphism and Susceptibility to Tuberculosis
نویسندگان
1 Mycobacteriology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
2 Mycobacteriology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
3 Department of Microbiology, Islamic Azad University, Jahrom Branch, Jahrom, Iran
doi
چکیده
Background: TNF-α as a pro-inflammatory cytokine plays a key role in host defense against tuberculosis (TB).Presence of mutation in TNF-α gene can influence the effectiveness, performance and capability of immuneresponses against this infection. The Aim of this study was to investigate the frequency of TNF-α alleles and itsrelationship with susceptibility to TB and TNF-α gene variations.Methods: A case-control study was conducted and 103 healthy controls and 93 TB patients were enrolled.Genotype of TNF-238, TNF -244, TNF-308, TNF -857 and TNF-863 were distinguished using PCR-RFLP method.Results: TNF-857 and TNF-863 were in high frequency mutation regions in a population level, and a significantdifference at TNF-857 was noticed between the two groups of case and control.Conclusion: Presence of mutation in TNF-857 region probably increases the host susceptibility to mycobacterialinfection. Genotyping of these regions in combination with other factors can be used for screening of high riskpersons. According to high distribution of mutations in TNF-857 and TNF-863 regions, further studies on associationof these regions is suggested.
