فهرست نشریات علمی دسترسی آزاد ایران

Background: Because economic data on the prophylactic usage of antibiotic in Iran are scant, we have conducteda cross-sectional study with provider perspective to measure costs and appropriate use of antibiotics insurgical wards of 6 training hospitals affiliated to Shiraz University of Medical Sciences (SUMS), Iran.Methods: Over a six-month period 1,000 consecutive patients undergoing surgical operation were enrolled andinformation on prophylactic antibiotic administration was collected. The information included basic patient'sdemographic data, types of surgery, category of antibiotic, dosage, dosage intervals, route of administration,number of doses, initiation times and duration of administration. In order to determine the agreement betweenprescribed antibiotics and medical indication, the American Society of Health-System Pharmacists (ASHP) guidelineswere applied.Results: Nine hundred and ninety three out of 1,000 patients (99.3%) had received at least one antibiotic and908 patients (91.4 %) received antibiotics because of a medical indication. Five out of 913 patients who hadindications for antibiotic prophylaxis did not receive any antibiotic. Antibiotics were prescribed for 85 out of 87(98%) procedures in which an antibiotic was not indicated. The average cost of antibiotic prescription per surgicalprocedure was 786,936 Iranian Rials (corresponding to 99.60 USD or €82.90). The most frequent prescribedantibiotic was cefazoline adding 53.3% of the total cost of antibiotics. In total, 36,516,190 Iranian Rials (correspondingto 4,622.95 USD or €3,845.20) were spent for cefazoline alone.Conclusion: The results of this study showed that all surgical patients received at least one antibiotic as prophylaxisfor any infection in the surgical site. Our results indicate over- and misuse of antibiotics in Iran leading to agreat amount of economic burden, since in 98% of all procedures, antibiotics were used inappropriately.