فهرست نشریات علمی دسترسی آزاد ایران

Background: The optimal antibiotic regimen is still controversial in open fractures. The purpose of this study wasto evaluate the efficacy of two different antibiotic regimens in management of type III-A open fractures.Methods: From January 2001 to January 2008, patients with type IIIA open fractures admitted in ShahidBeheshti Hospital Affiliated to Babol University of Medical Sciences were enrolled. Patients randomly receivedcefazolin plus gentamicin (group I) or cefazolin plus ciprofloxacin (group II). Both regimens were administered for3 days. All patients were followed for 3 months. The efficacy of both regimens was compared.Results: One hundred-forty eight and 153 patients were treated in group I and II, respectively. The mean age ofthe patients treated in group I was 36.96±14.4 and in group II was 36.93±13.51 years. The rate of deep infectionin group I was 5.4% and in group II was 6.5%. The efficacy of regimen I was 94.6% and regimen II was 93.5%.Conclusion: Cefazolin plus gentamicin, or cefazolin plus ciprofloxacin both can be successfully used for preventionof infection in type IIIA open fractures.