Interferon-Beta-1b Induced Autoimmune Hemolytic Anemia in a Patient with MS: A Case Report
نویسندگان
1 Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4 Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
doi
چکیده
A 26-year-old lady with the diagnosis of multiple sclerosis who had received interferon beta1-b for eleven monthswas visited in MS clinic of our hospital because of icter and fatigue. Laboratory tests showed anemia, indirecthyperbillirubinemia, increased LDH, positive direct and indirect coomb’s tests, and increased reticulocyte countand percentage. Other causes of autoimmune hemolytic anemia (AHA) and pre-existing AHA in the patient wereruled out. After INF discontinuation, symptoms disappeared, hemoglobin increased, and indirect coomb’s testbecame negative. We concluded that autoimmune hemolytic anemia should be considered in all MS patientswho receive interferon beta1-b and present with symptoms and signs of anemia.
