فهرست نشریات علمی دسترسی آزاد ایران

with prostate carcinogenesis and its progression toward advance metastatic or castration-resistant disease. Amajor objective of translational cancer research in post-genome era is to discover the repertoire of genetic andepigenetic variations associated with prostate cancer. Genome-wide association studies have been at leastpartially successful in identifying potential germline polymorphisms and allelic imbalances such as microsatelliteinstability and loss of heterozygosity associated with prostate cancer susceptibility. Epigenetic mechanisms suchas DNA hyper- or hypomethylation and histone modifications are reversible genetic alterations which allow stableinheritance of cellular phenotypes without any changes in the DNA sequence or quantity. Epigenetic modificationscan potentially be used for the molecular classification, detection, and risk assessment in prostate cancer.Chemical inhibitors of DNA methyltransferases and histone deacetylases have been used in different clinicaltrials and hold promise as novel chemotherapeutics to be effective alone or in combination with other therapeuticinterventions in prostate cancer.